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Can magnesium improve insulin resistance in patients with prediabetes?


Posted by Medivizor on Mar 3, 2020 in Diabetes mellitus |

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In a nutshell

This study looked at the effects of drinking magnesium-rich balanced deep-sea water in patients with prediabetes. This study found that this deep-sea water improved insulin sensitivity in these patients.

Some background

Individuals with prediabetes have high blood glucose levels, but not high enough to be diagnosed with diabetes. In diabetes, a patient’s cells become less sensitive to insulin. This means that their cells are not able to properly use blood glucose. As a result, blood glucose levels increase.

Balanced deep-sea water is purified water that contains minerals from deep in the ocean, including magnesium. Studies suggest that magnesium may help make cells more sensitive to insulin. Whether deep-sea water can improve symptoms of prediabetes is unclear.

Methods & findings

This study had 40 patients with prediabetes. 20 patients drank balanced deep-sea water containing magnesium every day for 8 weeks. 20 patients were given regular purified water (placebo). After 4 weeks, patients switched groups and drank the opposite type of water for 8 weeks. 

After 8 weeks, there was no difference in blood glucose levels between patients who had deep-sea water and patients who had regular purified water. Blood glucose levels decreased similarly in both groups after eating a meal after fasting (not eating) for 8 hours. 

HOMA-IR is a method of measuring how well cells respond to insulin. A high score means that a patient’s cells are sensitive to insulin. Patients who had deep-sea water had significantly lower scores (1.87) than the placebo group (2.13). Fasting insulin was also significantly lower (7.59 mg/dL vs. 8.62 mg/dL).

Total cholesterol significantly dropped by 5.68 mg/dL in the deep-sea water group compared to placebo (increase by 10.41 mg/dL). LDL cholesterol levels also significantly decreased in the deep-sea water group (by 7.22 mg/dL) but increased in the placebo group (by 11.00 mg/dL).

Deep-sea water was safe to drink. There were no differences in kidney function, blood cell levels, or blood pressure between the two groups.

The bottom line

This study found that deep-sea water containing magnesium improved insulin sensitivity in patients with prediabetes.

The fine print

This study had a small number of patients. Also, it was funded by the Korean Ministry of Oceans and Fisheries initiative to explore the uses of deep seawater.

Original Title :

Natural Magnesium-Enriched Deep-Sea Water Improves Insulin Resistance and the Lipid Profile of Prediabetic Adults: A Randomized, Double-Blinded Crossover Trial.

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